Orbitofrontal cortex

Orbitofrontal cortex

The Orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes in the brain which is involved in the cognitive processing of decision-making. The OFC is considered anatomically synonymous with the ventromedial prefrontal cortex. Therefore, the region is distinguished due to the distinct neural connections and the distinct functions it performs. It is defined as the part of the prefrontal cortex that receives projections from the magnocellular, medial nucleus of the mediodorsal thalamus, and is thought to represent emotion in decision making.

Etymology

The term "orbitofrontal cortex" derives from its position immediately above the orbits in which the eyes are located. "Orbito-" is a prefix from Latin "orbita" meaning "course, track" and "-frontal" is derived from Latin "frons" (forehead).

Anatomy

The OFC is divided into the medial and lateral OFC. The medial part is associated with monitoring the value of rewards and the lateral part is associated with evaluating punishments. The OFC contains the secondary olfactory cortex, which receives information about odours from the primary olfactory cortex.

Function

The orbitofrontal cortex plays a key role in decision making and expectation. It is involved in sensory integration, in representing the affective value of reinforcers, and in decision-making and expectation. The OFC is also involved in social and emotional processing, and lesions in this area can lead to deficits in interpreting and responding to social and emotional cues.

Clinical significance

Damage to the OFC can lead to a variety of disorders and abnormalities in cognitive function. These include impulsivity, compulsivity, mood disorders, and drug addiction. Patients with damage to the OFC can also exhibit personality changes and difficulty in making and following through with plans.

See also

• Prefrontal cortex
• Cognitive neuroscience
• Neuroanatomy

References

Orbitofrontal cortex Resources
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