Unoprostone

A prostaglandin analog used in ophthalmology

Unoprostone
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Unoprostone is a prostaglandin analog used primarily in the field of ophthalmology to manage conditions such as glaucoma and ocular hypertension. It functions by reducing intraocular pressure, which is crucial in preventing damage to the optic nerve and loss of vision.

Mechanism of Action

Unoprostone isopropyl, the active form of unoprostone, works by increasing the outflow of aqueous humor through the uveoscleral pathway. This action helps to lower intraocular pressure, which is beneficial in treating glaucoma and ocular hypertension. Unlike other prostaglandin analogs, unoprostone has a unique mechanism that may involve the activation of BK channels, contributing to its ocular hypotensive effects.

Clinical Use

Unoprostone is typically prescribed as an ophthalmic solution. Patients are advised to administer the drops once or twice daily, depending on the severity of their condition and the recommendation of their healthcare provider. It is important for patients to follow the prescribed regimen to achieve optimal results in lowering intraocular pressure.

Side Effects

Common side effects of unoprostone include mild eye irritation, conjunctival hyperemia, and changes in eyelash growth. Some patients may experience more serious side effects, such as changes in iris pigmentation or macular edema, although these are less common.

Comparison with Other Treatments

Unoprostone is one of several prostaglandin analogs available for the treatment of glaucoma. Others include latanoprost, bimatoprost, and travoprost. While all these medications share a similar mechanism of action, unoprostone is noted for its unique pharmacological properties and side effect profile.

Related pages

• Glaucoma
• Ocular hypertension
• Prostaglandin analogs
• Intraocular pressure

• Unoprostone