VEGF receptors

VEGF receptors are receptors for vascular endothelial growth factor (VEGF).

Angiogenesis

Angiogenesis is the formation of new blood vessels.

• This process involves the migration, growth, and differentiation of endothelial cells, which line the inside wall of blood vessels.
• The process of angiogenesis is controlled by chemical signals in the body such as vascular endothelial growth factor (VEGF), bind to receptors on the surface of normal endothelial cells.
• When VEGF and other endothelial growth factors bind to their receptors on endothelial cells, signals within the cells are initiated that promote the growth and survival of new blood vessels.

Types of receptors

There are 5 types:

1. VEGF (or VEGFA),
2. placental growth factor (PlGF),
3. VEGFB,
4. VEGFC and
5. FlGF (also known as VEGFD).

Subtypes

There are three main subtypes of VEGFR, numbered 1, 2 and 3.

(mbVEGFR)/(sVEGFR)

They may be membrane-bound (mbVEGFR) or soluble (sVEGFR), depending on alternative splicing.

VEGF inhibitors

Chemical signals, called angiogenesis inhibitors, interfere with blood vessel formation. Inhibitors of VEGFR are used in the treatment of cancer.

VEGF receptor inhibitors list

The list of VEGF receptor inhibitors include the following:

• Axitinib (Inlyta®)
• Bevacizumab (Avastin®)
• Cabozantinib (Cometriq®)
• Everolimus (Afinitor®)
• Lenalidomide (Revlimid®)
• Lenvatinib mesylate (Lenvima®)
• Pazopanib (Votrient®)
• Ramucirumab (Cyramza®)
• Regorafenib (Stivarga®)
• Sorafenib (Nexavar®)
• Sunitinib (Sutent®)
• Thalidomide (Synovir, Thalomid®)
• Vandetanib (Caprelsa®)
• Ziv-aflibercept (Zaltrap®)

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