VLDL

VLDL or Very Low-Density Lipoprotein is a type of lipoprotein made by the liver. VLDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, IDL, LDL, HDL) that enable fats and cholesterol to move within the water-based solution of the bloodstream.

Structure

VLDL particles are assembled in the liver from triglycerides, cholesterol, and apolipoproteins. VLDL particles are released from the liver into the bloodstream to supply body tissues with a type of fat, known as triglycerides.

Function

VLDL transports endogenous triglycerides, phospholipids, cholesterol, and cholesteryl esters. It functions as the body's internal transport mechanism for lipids and is responsible for the distribution of triglycerides to cells in the body.

Clinical significance

High levels of VLDL cholesterol have been associated with the development of plaque deposits on artery walls, which narrow the passage and restrict blood flow, a condition known as atherosclerosis. This can lead to diseases such as coronary artery disease.

Measurement

VLDL cholesterol levels are usually measured in a lipid panel along with triglycerides, LDL cholesterol, and HDL cholesterol. VLDL cholesterol is usually estimated as a percentage of your triglyceride value.

See also

• Cholesterol
• Lipoprotein
• Atherosclerosis
• Coronary artery disease

VLDL Resources
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