VN1R3

VN1R3 is a gene that encodes the Vomeronasal 1 receptor, D (VN1R1) protein in humans. This receptor is part of the vomeronasal organ (VNO), a chemosensory organ located in the nasal cavity that plays a crucial role in pheromone detection and social communication in many animals.

Structure

The VN1R3 gene is located on the short (p) arm of chromosome 19 at position 13.2. The encoded protein is a member of the G protein-coupled receptor (GPCR) superfamily, which is characterized by seven transmembrane domains, an extracellular N terminus, and an intracellular C terminus.

Function

The VN1R3 receptor is believed to detect chemical signals, or pheromones, in the environment and transmit these signals to the brain, influencing a variety of behaviors. However, the exact function of this receptor in humans is still under investigation. Some studies suggest that the human VNO may not be functional, while others propose that it may play a role in subconscious communication and mate selection.

Clinical Significance

While the clinical significance of VN1R3 is not yet fully understood, it is thought that mutations in this gene could potentially impact human behavior and social communication. Further research is needed to fully elucidate the role of this receptor in human health and disease.

See Also

• Vomeronasal organ
• Pheromone
• G protein-coupled receptor
• Chromosome 19

References

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