VPREB1
VPREB1 is a gene that encodes the pre-B lymphocyte protein 1 in humans. This protein is a component of the surrogate light chain (SLC), which is crucial for early B-cell development.
Function[edit | edit source]
VPREB1 is a part of the immunoglobulin superfamily and is expressed in early and late pre-B lymphocytes. It forms a complex with another protein, lambda 5, to form the surrogate light chain. This complex is involved in the early stages of B-cell development, specifically in the pre-B-cell receptor (pre-BCR) stage. The pre-BCR is a precursor to the B-cell receptor (BCR), which is essential for B-cell activation and immune response.
Clinical Significance[edit | edit source]
Mutations in the VPREB1 gene have been associated with various immune disorders. For instance, a decrease in VPREB1 expression has been observed in patients with common variable immunodeficiency (CVID), a disorder characterized by low levels of most or all of the immunoglobulin classes.
Furthermore, VPREB1 has been implicated in certain types of cancer, such as leukemia and lymphoma. In these cases, the VPREB1 gene is often found to be overexpressed, leading to an increase in early B-cell development and potentially contributing to the proliferation of cancerous cells.
Research[edit | edit source]
Research into the VPREB1 gene and its associated protein continues to be a significant area of interest in the field of immunology. Understanding the role of this gene in B-cell development and immune response could lead to new treatments for immune disorders and cancers.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
