VZV immune globulin

VZV Immune Globulin is a pharmaceutical drug used in the treatment and prevention of Varicella Zoster Virus (VZV) infections. It is a purified immunoglobulin preparation made from the plasma of healthy donors who have high levels of anti-VZV antibodies.

History

VZV Immune Globulin was first developed in the late 20th century as a means of providing passive immunity to individuals at high risk of severe VZV infection. It has since become a standard part of treatment protocols for certain patient populations.

Mechanism of Action

VZV Immune Globulin works by providing passive immunity to the recipient. The anti-VZV antibodies in the preparation bind to the virus, preventing it from infecting cells and replicating. This reduces the severity of the infection and can prevent it from occurring altogether if given soon after exposure.

Indications

VZV Immune Globulin is indicated for use in individuals at high risk of severe VZV infection, including those with weakened immune systems, pregnant women, newborns of mothers with chickenpox, and unvaccinated individuals exposed to VZV.

Side Effects

Like all medications, VZV Immune Globulin can cause side effects. These may include allergic reactions, fever, and pain or swelling at the injection site. More serious side effects, such as blood clots, are rare but can occur.

See Also

• Varicella Zoster Virus
• Immunoglobulin
• Passive immunity

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