Vadastuximab
Vadastuximab (also known as SGN-CD33A) is a monoclonal antibody designed for the treatment of acute myeloid leukemia (AML). It is developed by Seattle Genetics and is currently in the clinical trial phase.
Mechanism of Action[edit | edit source]
Vadastuximab targets the CD33 antigen, a protein abundantly expressed on the surface of AML cells. The antibody is conjugated with a potent, synthetic DNA cross-linking agent, a pyrrolobenzodiazepine (PBD) dimer, which is designed to be released inside the targeted cells upon internalization, causing cell death.
Clinical Trials[edit | edit source]
Vadastuximab has been evaluated in several clinical trials for the treatment of AML. The Phase 1 trial demonstrated a favorable safety profile and anti-leukemic activity. However, the Phase 3 CASCADE trial was halted in 2017 due to a higher rate of deaths observed in the vadastuximab arm compared to the control arm.
Future Development[edit | edit source]
Despite the setback in the CASCADE trial, Seattle Genetics continues to evaluate the potential of vadastuximab in other clinical settings and in combination with other therapies.
See Also[edit | edit source]
References[edit | edit source]
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