Vanishing testes

Vanishing testes syndrome, also known as anorchia or testicular regression syndrome, is a condition characterized by the absence of testes in males who have been confirmed to have a normal male karyotype at birth.

Etiology

The exact cause of vanishing testes syndrome is not well understood. It is believed to be due to a vascular event that occurs in utero, leading to the regression of the testes. This event is thought to occur after the testes have influenced the development of male genitalia, but before the production of sperm begins.

Diagnosis

Diagnosis of vanishing testes syndrome is typically made postnatally. It is often suspected in males who present with cryptorchidism, or undescended testes, particularly if both testes are undescended. Diagnostic tests may include ultrasound, magnetic resonance imaging (MRI), and hormone level testing.

Treatment

There is no cure for vanishing testes syndrome. Treatment is focused on managing the symptoms and complications of the condition. This may include hormone replacement therapy to provide the hormones that the testes would normally produce. Psychological support may also be beneficial due to the potential impact on the individual's gender identity and self-esteem.

Prognosis

The prognosis for individuals with vanishing testes syndrome varies. Some individuals may experience significant psychological distress, while others may not. The absence of testes also means that affected individuals are infertile.

See also

• Cryptorchidism
• Klinefelter syndrome
• Androgen insensitivity syndrome