Ventromedial nucleus of the hypothalamus

HypothalamicNuclei

Ventromedial nucleus of the hypothalamus

The ventromedial nucleus of the hypothalamus (VMN or VMH) is a distinct morphological nucleus situated within the hypothalamus. It plays a crucial role in regulating various physiological processes, including satiety, thermoregulation, and sexual behavior.

Anatomy

The VMN is located in the medial hypothalamus, bordered by the arcuate nucleus and the dorsomedial nucleus. It is composed of densely packed neurons and is divided into several subregions, each with specific functions.

Functions

Regulation of Satiety

The VMN is often referred to as the "satiety center" of the brain. It is involved in the regulation of food intake and energy homeostasis. Lesions in the VMN can lead to hyperphagia and obesity, while stimulation of this nucleus can induce feelings of fullness and reduce food consumption.

Thermoregulation

The VMN also plays a role in maintaining body temperature. It helps in the regulation of thermogenesis and heat dissipation processes, ensuring the body maintains a stable internal temperature.

Sexual Behavior

The VMN is implicated in the control of sexual behavior, particularly in females. It influences reproductive behavior and is involved in the regulation of hormonal cycles.

Neurotransmitters and Receptors

The VMN contains various neurotransmitters and receptors that mediate its functions. These include neuropeptide Y, leptin, and insulin receptors, which are crucial for its role in energy balance and metabolism.

Clinical Significance

Dysfunction of the VMN can lead to several disorders, including obesity, diabetes, and reproductive disorders. Understanding the VMN's role in these conditions is essential for developing targeted therapies.

Related Pages

• Hypothalamus
• Arcuate nucleus
• Dorsomedial nucleus
• Satiety
• Thermoregulation
• Sexual behavior
• Neuropeptide Y
• Leptin
• Insulin