Veratridine

Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by preventing the inactivation of sodium channels. It is used in biochemical experiments for its effects on sodium channels, which have been well-characterized.

Chemical Structure

Veratridine is a complex steroid-derived alkaloid. It is composed of a steroid nucleus with three additional rings attached. The molecule also contains several hydroxyl groups and a lactone ring.

Sources

Veratridine is found in plants in the Liliaceae family, including species of the genera Veratrum and Schoenocaulon. These plants are native to North America and parts of Europe and Asia.

Mechanism of Action

Veratridine acts as a neurotoxin by binding to voltage-gated sodium channels on neurons. This binding prevents the inactivation of the sodium channels, leading to a prolonged influx of sodium ions into the neuron. This results in a prolonged depolarization of the neuron, which can lead to cell death.

Uses

In biochemical research, veratridine is used for its effects on sodium channels. It is often used in experiments to study the properties of these channels, as its effects on them have been well-characterized.

Toxicity

Veratridine is highly toxic and can cause a variety of symptoms if ingested or absorbed through the skin. These can include nausea, vomiting, abdominal pain, and in severe cases, seizures or death.

Treatment

Treatment for veratridine poisoning is primarily supportive, with the goal of managing symptoms and preventing complications. This can include measures such as fluid replacement, seizure control, and in some cases, the use of drugs to counteract the effects of the toxin.

See Also

• Sodium channels
• Neurotoxin
• Veratrum

Veratridine Resources
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