Vornorexant
An article about the drug Vornorexant
Vornorexant is a medication that acts as a dual orexin receptor antagonist. It is primarily investigated for its potential use in the treatment of insomnia and other sleep disorders.
Mechanism of Action[edit | edit source]
Vornorexant works by selectively blocking the action of orexin neuropeptides. Orexins, also known as hypocretins, are neuropeptides that regulate arousal, wakefulness, and appetite. By inhibiting the binding of orexins to their receptors, Vornorexant promotes sleep by reducing wakefulness.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of Vornorexant includes its absorption, distribution, metabolism, and excretion. After oral administration, Vornorexant is absorbed into the bloodstream and distributed throughout the body. It is metabolized primarily in the liver and excreted via the kidneys.
Clinical Trials[edit | edit source]
Vornorexant has undergone several clinical trials to evaluate its efficacy and safety in treating insomnia. These trials assess various parameters such as sleep onset latency, total sleep time, and sleep quality.
Side Effects[edit | edit source]
Common side effects of Vornorexant may include drowsiness, headache, and dizziness. As with any medication, it is important to monitor for adverse effects and consult a healthcare provider if they occur.
Potential Uses[edit | edit source]
While primarily studied for insomnia, Vornorexant may have potential applications in other conditions related to sleep disturbances, such as narcolepsy and shift work sleep disorder.
Related pages[edit | edit source]
Vornorexant
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