WDR26

WDR26

WDR26 is a gene that encodes for the protein WD repeat domain 26. This protein is involved in various cellular processes and has been found to play a role in the development and function of different tissues and organs.

Gene Structure and Function

The WDR26 gene is located on chromosome 10 in humans. It spans approximately 20 kilobases and consists of 14 exons. The protein encoded by this gene contains multiple WD40 repeat domains, which are known to mediate protein-protein interactions.

The exact function of WDR26 is not yet fully understood, but studies have suggested its involvement in several cellular processes. It has been implicated in the regulation of cell cycle progression, DNA repair, and chromatin remodeling. Additionally, WDR26 has been found to interact with other proteins involved in transcriptional regulation and RNA processing.

Role in Development and Disease

Research has shown that WDR26 is essential for the proper development and function of various tissues and organs. In mice, the loss of WDR26 has been associated with defects in embryonic development, including abnormalities in neural tube closure and heart development.

Furthermore, studies have linked mutations in the WDR26 gene to certain human diseases. For example, mutations in WDR26 have been found in individuals with intellectual disability and developmental delay. These findings suggest that WDR26 plays a crucial role in normal brain development and function.

Clinical Implications

Understanding the function and role of WDR26 in development and disease has important clinical implications. The identification of WDR26 mutations in individuals with intellectual disability and developmental delay can aid in genetic counseling and provide insights into potential therapeutic targets.

Furthermore, further research on WDR26 may uncover its involvement in other diseases and cellular processes. This knowledge could potentially lead to the development of novel diagnostic tools and therapeutic interventions.

References

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See Also

• Genetics
• Protein-protein interaction
• Chromatin remodeling
• Intellectual disability
• Developmental delay