WDR37

WDR37

WDR37 is a gene that encodes a protein known as WD repeat-containing protein 37. This protein is found in humans and is involved in various cellular processes. The gene is located on chromosome 10q26.3 and is conserved across different species.

Function

The WDR37 protein belongs to the WD repeat family, which is characterized by the presence of multiple copies of a conserved sequence motif called the WD repeat. These repeats are involved in protein-protein interactions and play a crucial role in various cellular processes, including signal transduction, cell cycle regulation, and protein folding.

WDR37 has been shown to interact with other proteins involved in DNA repair and cell cycle regulation. It is believed to play a role in maintaining genomic stability and preventing the accumulation of DNA damage. Additionally, WDR37 has been implicated in the regulation of gene expression and protein synthesis.

Clinical Significance

Mutations in the WDR37 gene have been associated with certain genetic disorders. For example, a study identified a mutation in WDR37 in a patient with a rare form of intellectual disability. This suggests that WDR37 may be involved in normal brain development and function.

Furthermore, dysregulation of WDR37 expression has been observed in various types of cancer. Studies have shown that WDR37 is overexpressed in certain cancer cells, and its expression levels correlate with tumor progression and poor prognosis. This suggests that WDR37 may have a role in cancer development and progression, making it a potential target for therapeutic interventions.