WDR44

WDR44

WDR44 is a protein-coding gene that is also known as WD repeat domain 44. It is located on chromosome 1 in humans and is conserved across various species. The gene encodes a protein that belongs to the WD repeat family, which is involved in a wide range of cellular processes.

Function

The exact function of WDR44 is not yet fully understood. However, studies have suggested its involvement in several cellular processes, including protein-protein interactions, signal transduction, and gene expression regulation. It is believed to play a role in the assembly and stability of protein complexes, as well as in the modulation of cellular pathways.

Structure

WDR44 consists of multiple WD repeat domains, which are characterized by a conserved sequence motif of approximately 40-60 amino acids. These repeats form a β-propeller structure, which facilitates protein-protein interactions. The specific arrangement and number of WD repeats in WDR44 may contribute to its unique functions and interactions with other proteins.

Clinical Significance

Research on WDR44's clinical significance is still ongoing, and its exact role in human diseases is not yet fully understood. However, some studies have suggested its potential involvement in certain cancers and neurological disorders. Further investigations are required to determine the precise mechanisms and implications of WDR44 in these conditions.