WFIKKN2

WFIKKN2 (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain containing 2) is a protein that in humans is encoded by the WFIKKN2 gene. This protein is known to have a role in tissue repair and regeneration, particularly in the muscle and connective tissues.

Function

WFIKKN2 is a secreted protein that contains multiple protein-protein interaction domains. It is known to bind growth factors and other extracellular proteins, and modulate their activity. The protein is involved in tissue repair and regeneration, and has been shown to promote muscle cell differentiation and inhibit muscle cell proliferation.

Clinical significance

Mutations in the WFIKKN2 gene have been associated with a variety of diseases, including muscular dystrophy and sarcopenia, a condition characterized by loss of muscle mass and strength. Research is ongoing to understand the role of WFIKKN2 in these conditions and to develop potential therapies.

See also

• WFIKKN1
• Growth differentiation factor 8
• Myostatin

External links

• NCBI Gene
• UniProt