Wasabi receptor toxin

Error creating thumbnail:

Urodacus manicatus2

Wasabi receptor toxin (WaTx) is a peptide toxin derived from the venom of the Japanese black-banded sea krait (Laticauda semifasciata). This toxin is known for its ability to activate the TRPA1 receptor, which is also known as the wasabi receptor due to its activation by allyl isothiocyanate, the pungent compound found in wasabi.

Structure and Function

WaTx is a small peptide consisting of 33 amino acids. It has a unique structure that allows it to interact specifically with the TRPA1 receptor. The activation of TRPA1 by WaTx leads to the sensation of pain and inflammation, similar to the effects produced by wasabi and other pungent substances.

Mechanism of Action

The TRPA1 receptor is a member of the transient receptor potential (TRP) family of ion channels. It is expressed in sensory neurons and is involved in the detection of noxious stimuli. When WaTx binds to TRPA1, it causes the channel to open, allowing the influx of calcium ions into the cell. This influx of calcium ions triggers a cascade of events that result in the sensation of pain and inflammation.

Biological Significance

The discovery of WaTx has provided valuable insights into the functioning of the TRPA1 receptor and its role in pain and inflammation. It has also opened up new avenues for the development of novel pain therapeutics targeting the TRPA1 receptor.

Research and Applications

Research on WaTx and its interaction with TRPA1 is ongoing. Scientists are exploring the potential of WaTx as a tool for studying TRPA1 function and as a lead compound for the development of new pain-relief medications. The specificity of WaTx for TRPA1 makes it a valuable molecule for these purposes.

Related Pages

• TRPA1
• Transient receptor potential channel
• Japanese black-banded sea krait
• Pain
• Inflammation