Collagenase clostridium histolyticum

Collagenase Clostridium Histolyticum is a medical treatment used primarily in the management of Dupuytren's contracture and Peyronie's disease. It is a mixture of two collagenases, enzymes that break down collagen in the body, produced by the bacterium Clostridium histolyticum.

Medical Uses[edit | edit source]

Collagenase Clostridium Histolyticum is used in the treatment of Dupuytren's contracture, a condition that affects the hands and fingers, causing one or more fingers to bend into the palm of the hand. It is also used in the treatment of Peyronie's disease, a condition in which fibrous scar tissue develops on the penis, causing curved, painful erections.

Mechanism of Action[edit | edit source]

The two collagenases in Collagenase Clostridium Histolyticum work by breaking down collagen, a protein that forms part of the body's connective tissues. This helps to dissolve the excess collagen that causes the contractures in Dupuytren's and the plaques in Peyronie's.

Side Effects[edit | edit source]

Common side effects of Collagenase Clostridium Histolyticum include swelling, bruising, and pain at the injection site. More serious side effects can include allergic reactions, tendon rupture, and injury to nearby nerves or blood vessels.

History[edit | edit source]

Collagenase Clostridium Histolyticum was first approved for medical use in the United States in 2010. It is marketed under the brand name Xiaflex in the U.S. and Xiapex in Europe.