YM-31636

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YM-31636 is a drug that acts as a 5-HT4 receptor agonist. It is primarily used in the treatment of gastrointestinal disorders, such as irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD).

Pharmacology[edit | edit source]

YM-31636 works by stimulating the 5-HT4 receptors in the gastrointestinal tract. This leads to an increase in the release of acetylcholine, which in turn stimulates the muscles in the gastrointestinal tract to contract more frequently and with greater force. This helps to speed up the passage of food through the digestive system, relieving symptoms such as bloating, constipation and abdominal pain.

Clinical Use[edit | edit source]

YM-31636 has been shown to be effective in the treatment of a number of gastrointestinal disorders. In clinical trials, it has been shown to significantly improve symptoms in patients with IBS, and to reduce the frequency and severity of heartburn in patients with GERD. It is generally well tolerated, with the most common side effects being mild and transient, such as headache and nausea.

Research[edit | edit source]

Research into the potential uses of YM-31636 is ongoing. Some studies have suggested that it may also have potential in the treatment of other conditions, such as Parkinson's disease, due to its ability to stimulate the release of acetylcholine, a neurotransmitter that is often deficient in this condition. However, further research is needed to confirm these findings and to fully understand the potential benefits and risks of this drug.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD