YadA bacterial adhesin protein domain

PDB 2gr8 EBI

YadA Bacterial Adhesin Protein Domain

The YadA bacterial adhesin protein domain is a protein domain found in certain bacterial adhesins, specifically in the YadA protein family. Adhesins are proteins that enable bacteria to adhere to host cells or surfaces, facilitating colonization and infection. The YadA protein family is known for its role in mediating bacterial adhesion to host tissues.

The YadA protein domain is characterized by its structural features, including a beta-roll motif and a stalk region that extends from the bacterial surface. These structural elements are essential for the adhesion function of the YadA protein, allowing the bacteria to bind to specific receptors on host cells.

Studies have shown that the YadA protein domain plays a critical role in the virulence of certain pathogenic bacteria. By promoting adhesion to host tissues, bacteria expressing the YadA protein domain can establish infections and evade host immune responses. Understanding the molecular mechanisms underlying YadA-mediated adhesion is important for developing strategies to combat bacterial infections.

Research on the YadA bacterial adhesin protein domain continues to uncover new insights into bacterial pathogenesis and host-pathogen interactions. By elucidating the structure and function of this protein domain, scientists aim to identify potential targets for therapeutic intervention to disrupt bacterial adhesion and prevent infections.

See also

• Adhesin
• Bacterial adhesion
• Virulence factor