Yohimbane

Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree and other related species. It is commonly used as a stimulant and aphrodisiac, and has also been used in traditional medicine for its potential therapeutic properties.

Chemistry

Yohimbine is a member of the alkaloid family, a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. It is an indole alkaloid, which means it has a structure based on the indole basic skeleton, a bicyclic molecule made up of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.

Pharmacology

Yohimbine acts as an antagonist at alpha-2 adrenergic receptors, thereby increasing the release of norepinephrine. This action is thought to be responsible for its stimulant effects. Yohimbine has also been found to increase blood flow by dilating blood vessels, which can contribute to its aphrodisiac effects.

Medical uses

Yohimbine has been used in the treatment of erectile dysfunction, as it is thought to help increase blood flow to the penis. However, the evidence supporting its effectiveness for this use is limited and inconsistent. Some studies have suggested that yohimbine may also be useful in the treatment of sexual dysfunction related to selective serotonin reuptake inhibitor (SSRI) use.

Side effects

Common side effects of yohimbine include increased heart rate, high blood pressure, anxiety, dizziness, and sleep problems. It can also cause more serious side effects such as rapid heart rate, high blood pressure, and anxiety. Yohimbine should be used with caution in individuals with heart disease, high blood pressure, or anxiety disorders.

See also

• Pausinystalia yohimbe
• Alkaloid
• Indole