ZNF202

ZNF202 is a gene that encodes a zinc finger protein in humans. It is also known as Zinc Finger Protein 202 and is a member of the Krüppel-type zinc finger protein family.

Function

The ZNF202 gene is involved in the regulation of lipid metabolism. It acts as a transcriptional repressor binding to DNA sequences in the promoter regions of target genes. The protein encoded by this gene is a transcription factor that represses the transcription of genes involved in lipoprotein metabolism, including apolipoprotein E, apolipoprotein CIII, and low-density lipoprotein receptor.

Clinical Significance

Mutations in the ZNF202 gene have been associated with hyperlipidemia, a condition characterized by an excess of fats in the blood. This can lead to an increased risk of cardiovascular disease.

Structure

The ZNF202 protein contains five C2H2-type zinc fingers, which are the most common type of zinc finger and are crucial for the protein's function as a transcription factor. These zinc fingers allow the protein to bind to specific DNA sequences, enabling it to regulate the transcription of target genes.

Expression

ZNF202 is expressed in a variety of tissues, with the highest levels found in the liver, heart, and skeletal muscle. Its expression is regulated by dietary cholesterol and fatty acids, suggesting a role in the body's response to dietary lipids.

See Also

• Zinc finger
• Transcription factor
• Hyperlipidemia