ZNF274

ZNF274 or Zinc Finger Protein 274 is a protein that in humans is encoded by the ZNF274 gene. This protein is a member of the zinc finger family of proteins, which are regulatory proteins that can bind to DNA, RNA, protein and/or lipid substrates.

Function

ZNF274 is a transcriptional repressor that binds to promoter regions of a number of genes. It is involved in various biological processes such as cell cycle regulation, apoptosis, and DNA damage response. The protein is known to interact with other proteins such as PRMT5 and COPR5, which are involved in gene silencing and methylation processes.

Clinical Significance

Alterations in the ZNF274 gene have been associated with several diseases. For instance, mutations in this gene have been linked to cancer, particularly breast cancer and prostate cancer. It is also implicated in neurodevelopmental disorders and autoimmune diseases.

Structure

The ZNF274 protein contains several zinc finger domains, which are common motifs in DNA-binding proteins. These domains allow the protein to interact with specific sequences of DNA, thereby regulating gene expression.

Research

Research on ZNF274 is ongoing, with studies focusing on its role in disease development and potential as a therapeutic target. For example, researchers are investigating how alterations in the ZNF274 gene contribute to cancer development and progression.

See Also

• Zinc finger
• Transcription (genetics)
• Gene expression
• DNA-binding protein