ZNF365

ZNF365 is a human gene that encodes for the protein ZNF365. This protein is a member of the zinc finger protein family and is involved in DNA binding and gene expression regulation.

Function

The ZNF365 gene is known to play a crucial role in various biological processes. It is involved in the regulation of cell cycle, DNA repair, and telomere maintenance. The protein encoded by this gene is also implicated in the pathogenesis of several diseases, including breast cancer and Crohn's disease.

Structure

The ZNF365 gene is located on the short (p) arm of chromosome 10 at position 21. It spans approximately 70 kilobases and consists of 13 exons. The encoded protein contains a C2H2-type zinc finger domain, which is responsible for its DNA-binding activity.

Clinical significance

Mutations in the ZNF365 gene have been associated with a higher risk of developing breast cancer. A specific variant of this gene, rs10822013, has been linked to an increased susceptibility to this disease. In addition, polymorphisms in ZNF365 have been found to be associated with Crohn's disease, a type of inflammatory bowel disease.

Research

Research on the ZNF365 gene is ongoing, with studies focusing on its role in disease pathogenesis and potential as a therapeutic target. For instance, researchers are investigating the mechanisms by which ZNF365 mutations contribute to cancer development and progression.

See also

• Zinc finger protein
• DNA binding
• Gene expression regulation
• Breast cancer
• Crohn's disease