ZNF366

ZNF366 also known as Zinc Finger Protein 366 is a protein that in humans is encoded by the ZNF366 gene. The protein encoded by this gene is a zinc finger protein, a family of proteins characterized by the presence of one or more zinc finger domains. Zinc fingers are protein domains that can bind to DNA, RNA, proteins, and/or lipids.

Function[edit | edit source]

ZNF366 is a transcriptional repressor that plays a role in various biological processes. It is involved in the regulation of cell proliferation, apoptosis, and cell cycle progression. It is also implicated in the development of certain types of cancer, including breast cancer and ovarian cancer.

Structure[edit | edit source]

The ZNF366 protein contains six C2H2-type zinc fingers, which are involved in binding to specific DNA sequences. The protein also contains a BTB/POZ domain, which is involved in protein-protein interactions.

Clinical Significance[edit | edit source]

Alterations in the ZNF366 gene have been associated with various types of cancer. For example, overexpression of ZNF366 has been observed in breast cancer and ovarian cancer. It is thought that ZNF366 may promote cancer development by inhibiting apoptosis and promoting cell proliferation.

Research[edit | edit source]

Research is ongoing to further understand the role of ZNF366 in cancer development and to explore the potential of targeting ZNF366 for cancer therapy.