ZRF1

Ideogram human chromosome 7

ZRF1

ZRF1 is a gene that plays a crucial role in various biological processes. It is located on chromosome 8 in humans and is highly conserved across different species. The ZRF1 gene encodes a protein that functions as a transcriptional regulator, influencing the expression of genes involved in cell growth, development, and differentiation.

Function

The ZRF1 protein is known to interact with chromatin remodeling complexes, such as the SWI/SNF complex, to modulate gene expression. It has been implicated in the regulation of embryonic stem cell pluripotency and differentiation. Additionally, ZRF1 has been linked to the DNA damage response pathway, suggesting its involvement in maintaining genomic stability.

Clinical Significance

Mutations in the ZRF1 gene have been associated with certain developmental disorders and cancers. Dysregulation of ZRF1 expression has been observed in various tumor types, highlighting its potential as a therapeutic target for cancer treatment.

Research

Research on ZRF1 is ongoing to further elucidate its molecular functions and biological significance. Studies are focused on understanding how ZRF1 contributes to normal cellular processes and how its dysregulation can lead to disease states.

See also

• Chromosome 8
• Gene expression
• Transcriptional regulation