Zastaprazan

Zastaprazan

Chemical structure of Zastaprazan

Zastaprazan is a pharmaceutical compound that belongs to the class of proton pump inhibitors (PPIs). It is primarily used in the treatment of conditions related to excessive stomach acid production, such as gastroesophageal reflux disease (GERD) and peptic ulcer disease.

Mechanism of Action

Zastaprazan functions by inhibiting the H+/K+ ATPase enzyme system, commonly known as the gastric proton pump, located in the parietal cells of the stomach lining. This inhibition prevents the final step of acid production, thereby reducing gastric acidity. By decreasing stomach acid, Zastaprazan helps in alleviating symptoms associated with acid-related disorders and promotes healing of the gastric mucosa.

Clinical Uses

Zastaprazan is indicated for the management of several gastrointestinal conditions, including:

• Gastroesophageal Reflux Disease (GERD): A chronic condition where stomach acid frequently flows back into the esophagus, causing irritation.
• Peptic Ulcer Disease: A condition characterized by sores or ulcers developing in the lining of the stomach or the first part of the small intestine.
• Zollinger-Ellison Syndrome: A rare condition involving tumors in the pancreas or duodenum that cause excessive production of stomach acid.

Pharmacokinetics

Zastaprazan is administered orally and is absorbed in the small intestine. It undergoes hepatic metabolism primarily via the cytochrome P450 enzyme system. The drug is then excreted through the kidneys. The pharmacokinetic profile of Zastaprazan allows for once-daily dosing, which is convenient for patients.

Side Effects

Common side effects of Zastaprazan include headache, nausea, diarrhea, abdominal pain, and dizziness. Long-term use of proton pump inhibitors, including Zastaprazan, has been associated with an increased risk of osteoporosis-related fractures, Clostridium difficile infection, and hypomagnesemia.

Drug Interactions

Zastaprazan may interact with other medications metabolized by the cytochrome P450 system, such as warfarin, diazepam, and phenytoin. It can also affect the absorption of drugs that require an acidic environment for optimal absorption, such as ketoconazole and iron supplements.

Related Pages

• Proton pump inhibitor
• Gastroesophageal reflux disease
• Peptic ulcer disease
• Zollinger-Ellison syndrome