Zibotentan

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Zibotentan is a medication that belongs to a class of drugs known as endothelin receptor antagonists. It is primarily used in the treatment of certain types of cancer, specifically advanced prostate cancer. Zibotentan works by blocking the action of endothelin, a substance in the body that can promote the growth and spread of cancer cells.

Mechanism of Action[edit | edit source]

Zibotentan exerts its effects by selectively blocking the endothelin A receptor, which is involved in regulating blood vessel constriction and cell growth. By inhibiting this receptor, zibotentan helps to reduce the blood supply to tumors, thereby slowing down their growth and potentially shrinking them.

Indications[edit | edit source]

Zibotentan is indicated for the treatment of patients with metastatic castration-resistant prostate cancer. It is typically used in combination with other cancer medications or therapies as part of a comprehensive treatment plan.

Dosage and Administration[edit | edit source]

The recommended dose of zibotentan for prostate cancer is typically 10 mg once daily. It is usually taken orally with or without food. The exact dosing regimen may vary depending on the individual patient's condition and response to treatment.

Side Effects[edit | edit source]

Common side effects associated with zibotentan may include nausea, fatigue, decreased appetite, and high blood pressure. In some cases, more serious side effects such as liver toxicity or allergic reactions may occur. Patients should be closely monitored for any adverse effects while taking this medication.

Precautions[edit | edit source]

Before starting treatment with zibotentan, patients should inform their healthcare provider about any pre-existing medical conditions or medications they are taking. Zibotentan may interact with certain drugs, so it is important to discuss potential drug interactions with a healthcare professional.

Clinical Trials[edit | edit source]

Clinical trials have been conducted to evaluate the safety and efficacy of zibotentan in the treatment of prostate cancer. These studies have shown promising results in terms of slowing disease progression and improving overall survival rates in some patients.

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Zibotentan[edit | edit source]

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