Ziconotide

Ziconotide is a non-opioid analgesic that is used for the management of severe chronic pain. It is a synthetic form of a naturally occurring conotoxin peptide found in the venom of a marine snail species known as Conus magus. Ziconotide works by blocking N-type voltage-sensitive calcium channels, which leads to the inhibition of the release of pain neurotransmitters in the brain.

History

Ziconotide was discovered in the early 1980s by Baldomero Olivera, a biochemist at the University of Utah. The drug was approved by the Food and Drug Administration (FDA) in the United States in 2004.

Mechanism of Action

Ziconotide functions by blocking N-type voltage-sensitive calcium channels in the brain. This action inhibits the release of pain neurotransmitters, thereby reducing the sensation of pain. Unlike opioids, ziconotide does not have any known risk of addiction or tolerance.

Uses

Ziconotide is used for the management of severe chronic pain that cannot be controlled by other pain medications. It is administered intrathecally, or directly into the spinal fluid.

Side Effects

Common side effects of ziconotide include nausea, dizziness, and confusion. In some cases, it can also cause serious neurological and psychiatric side effects.

See Also

• Conotoxin
• Analgesic
• Chronic Pain

References

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  Structural formula of ziconotide
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  Ziconotide 1DW5