Zosteriform speckled lentiginous nevus

Zosteriform Speckled Lentiginous Nevus (ZSLN) is a rare type of skin lesion that presents as a speckled, lentiginous nevus following a zosteriform distribution. This condition is characterized by the presence of numerous small, darkly pigmented spots (lentigines) scattered within a larger, lightly pigmented patch of skin. The distribution of the lesion typically follows dermatomal lines, resembling the pattern seen in herpes zoster infections, hence the name zosteriform.

Etiology and Pathogenesis[edit | edit source]

The exact cause of Zosteriform Speckled Lentiginous Nevus remains unclear. It is believed to be a type of congenital melanocytic nevus, which means it is present at birth or develops shortly thereafter. The condition is not caused by viral infections like herpes zoster, despite its name suggesting a similar pattern of distribution. Genetic factors may play a role in its development, but specific genetic mutations associated with ZSLN have not been identified.

Clinical Features[edit | edit source]

Patients with Zosteriform Speckled Lentiginous Nevus typically present with a single, unilateral patch of skin that is irregular in shape and has a speckled appearance due to the presence of multiple darkly pigmented lentigines. The background skin may be hyperpigmented or hypopigmented. The lesion is usually present at birth or appears in early childhood and does not regress spontaneously. It is most commonly located on the trunk or limbs, following a dermatomal distribution.

Diagnosis[edit | edit source]

Diagnosis of Zosteriform Speckled Lentiginous Nevus is primarily clinical, based on the characteristic appearance and distribution of the lesion. Dermoscopy can be helpful in distinguishing ZSLN from other pigmented skin lesions by revealing the typical features of lentigines within the nevus. In uncertain cases, a skin biopsy may be performed to confirm the diagnosis histologically.

Treatment and Management[edit | edit source]

There is no specific treatment required for Zosteriform Speckled Lentiginous Nevus, as it is generally a benign condition. However, patients should be monitored for changes in the lesion, as there is a small risk of malignant transformation into melanoma. Cosmetic treatments, such as laser therapy, may be considered for aesthetic reasons or if the lesion causes psychological distress.

Prognosis[edit | edit source]

The prognosis for individuals with Zosteriform Speckled Lentiginous Nevus is generally good, as it is a benign condition. However, due to the potential risk of melanoma development within the lesion, regular follow-up with a dermatologist is recommended to monitor for any changes.