Α-Hydroxyetizolam
Α-Hydroxyetizolam is a metabolite of the thienodiazepine etizolam, which is a compound structurally related to benzodiazepines. Α-Hydroxyetizolam is formed in the liver through the process of metabolism and has pharmacological activity similar to its parent compound, etizolam, though typically with a lower potency. The presence of Α-Hydroxyetizolam in biological specimens can be an indicator of etizolam consumption.
Pharmacology[edit | edit source]
Α-Hydroxyetizolam, like etizolam, acts as an agonist at the GABAA receptor, which is the most prolific inhibitory receptor within the brain. This action enhances the effect of the neurotransmitter GABA (gamma-aminobutyric acid), leading to increased neuronal inhibition and the manifestation of the typical effects of thienodiazepines: muscle relaxation, anxiolysis, sedation, and anticonvulsant effects.
Metabolism[edit | edit source]
The metabolism of etizolam to Α-Hydroxyetizolam primarily occurs in the liver, mediated by enzymes of the cytochrome P450 family. This metabolic pathway is crucial for the elimination of etizolam from the body and can influence the duration of its pharmacological effects. The detection of Α-Hydroxyetizolam in urine or blood tests can be used to confirm recent use of etizolam, making it significant in the fields of toxicology and forensic science.
Clinical Significance[edit | edit source]
While Α-Hydroxyetizolam itself is not marketed as a therapeutic agent, its parent compound, etizolam, is used in certain countries for the treatment of anxiety and insomnia. Understanding the metabolism of etizolam, including the formation of Α-Hydroxyetizolam, is important for clinicians to predict drug interactions, side effects, and the duration of action of etizolam.
Legal Status[edit | edit source]
The legal status of Α-Hydroxyetizolam is generally tied to that of etizolam, which varies by country. In some jurisdictions, etizolam and its metabolites are controlled substances due to their potential for abuse and dependence.
See Also[edit | edit source]
- Etizolam
- Thienodiazepine
- Benzodiazepine
- [[GABAA receptor]]
- Cytochrome P450
Transform your life with W8MD's budget GLP1 injections from $125
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
- Budget GLP1 weight loss injections in NYC starting from $125.00 biweekly with insurance!
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD