Δ5-Androstenediol
Δ5-Androstenediol (also known as 5-Androstenediol, Androst-5-ene-3β,17β-diol) is a steroid hormone that is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, DHEA. It is less androgenic than DHEA and exerts significant estrogenic effects.
Chemistry[edit | edit source]
Δ5-Androstenediol is a androstane steroid and a delta-5 steroid. It is also a prohormone by being a precursor to testosterone.
Biological function[edit | edit source]
Δ5-Androstenediol is converted into testosterone via the enzyme 17β-hydroxysteroid dehydrogenase. It can also be converted into estrone via aromatase, an enzyme that converts testosterone into estrone.
Clinical significance[edit | edit source]
Δ5-Androstenediol has been investigated for use in treating menopause and osteoporosis, but it is not widely used for these indications. It has also been studied for use in treating hypogonadism.
See also[edit | edit source]
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