Δ7-Prednisolone

Δ7-Prednisolone is a synthetic glucocorticoid drug with potent anti-inflammatory and immunosuppressive properties. It is a derivative of prednisolone, distinguished by the presence of a double bond at the 7th position of the steroid nucleus.

Chemistry

Δ7-Prednisolone is a corticosteroid that is chemically classified as a steroid. It is characterized by a Δ7 double bond in the B ring of the steroid nucleus, which is not present in its parent compound, prednisolone. This modification enhances the drug's anti-inflammatory and immunosuppressive activity.

Pharmacology

Like other glucocorticoids, Δ7-Prednisolone exerts its effects by binding to glucocorticoid receptors in the cytoplasm of target cells. Upon binding, the receptor-ligand complex translocates to the nucleus, where it regulates the transcription of target genes. This leads to changes in the production of proteins that mediate inflammation and immune responses.

Clinical Use

Δ7-Prednisolone is used in the treatment of a variety of conditions that involve inflammation and overactive immune responses. These include rheumatoid arthritis, asthma, allergies, and certain autoimmune diseases. It is also used in the management of organ transplant patients to prevent rejection.

Side Effects

As with other glucocorticoids, long-term use of Δ7-Prednisolone can lead to side effects such as osteoporosis, glaucoma, Cushing's syndrome, and an increased risk of infections due to its immunosuppressive effects. Therefore, the drug should be used under the supervision of a healthcare provider and the dosage should be carefully adjusted to minimize these risks.

See Also

• Prednisolone
• Glucocorticoid
• Corticosteroid
• Glucocorticoid receptor