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Bis(trifluoroacetoxy)iodo)benzene (BTI) is a chemical compound used in organic synthesis. It is a versatile reagent that introduces iodine into organic molecules and converts some functional groups into more reactive or useful ones.

Structure and Properties[edit | edit source]

BTI is a solid at room temperature. Its molecular structure consists of a benzene ring with an iodine atom attached, and two trifluoroacetoxy groups attached to the iodine. The trifluoroacetoxy groups are electron-withdrawing, which makes the iodine more electrophilic and therefore more reactive.

Synthesis[edit | edit source]

BTI can be synthesized from iodobenzene and trifluoroacetic anhydride. The reaction is typically carried out in a solvent such as dichloromethane.

Uses[edit | edit source]

BTI is used in organic synthesis as an oxidizing agent. It can convert alcohols to aldehydes or ketones, and it can introduce iodine into organic molecules. It is also used to convert some functional groups into more reactive or useful ones. For example, it can convert alcohols into iodides, which can then be used in further reactions.

Safety[edit | edit source]

BTI is a strong oxidizer and can cause burns. It should be handled with care, using appropriate personal protective equipment. It should be stored in a cool, dry place, away from sources of ignition.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD