1,3,5-Trithiane

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A chemical compound used as a formaldehyde equivalent


1,3,5-Trithiane
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1,3,5-Trithiane is a heterocyclic compound with the formula (CH2S)3. It is a cyclic trimer of thioformaldehyde. This compound is a white crystalline solid that is soluble in organic solvents.

Structure and properties[edit | edit source]

1,3,5-Trithiane is a six-membered ring containing three carbon atoms and three sulfur atoms. The compound is a sulfur analog of 1,3,5-trioxane, where the oxygen atoms are replaced by sulfur atoms. The presence of sulfur atoms imparts unique chemical properties to the compound, including its ability to act as a formaldehyde equivalent in various chemical reactions.

Synthesis[edit | edit source]

1,3,5-Trithiane can be synthesized by the acid-catalyzed trimerization of thioformaldehyde. This reaction involves the condensation of three molecules of thioformaldehyde to form the cyclic trimer. The process is typically carried out in the presence of an acid catalyst, such as hydrochloric acid or sulfuric acid.

Applications[edit | edit source]

1,3,5-Trithiane is used in organic synthesis as a source of formaldehyde. It can be used in the formylation of nucleophiles, where it acts as a formaldehyde equivalent. This property makes it valuable in the synthesis of various organic compounds.

Safety and handling[edit | edit source]

As with many sulfur-containing compounds, 1,3,5-Trithiane should be handled with care. It is important to use appropriate personal protective equipment (PPE) and work in a well-ventilated area to avoid exposure to potentially harmful vapors.

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Contributors: Prab R. Tumpati, MD