1,5-anhydro-D-glucitol

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1,5-Anhydro-D-glucitol (also known as 1,5-AG) is a naturally occurring monosaccharide found in nearly all foods. It is used as a marker for average blood glucose concentration over time.

Overview[edit | edit source]

1,5-Anhydro-D-glucitol is a polyol, a type of sugar alcohol, that is metabolized in the human body. It is absorbed from food and is excreted into the urine. A decrease in 1,5-AG levels in the body is an indicator of poor glycemic control and can be used to monitor the efficacy of diabetes treatment plans.

Role in Diabetes Monitoring[edit | edit source]

In individuals without diabetes, the amount of 1,5-AG in the body remains relatively constant. However, in individuals with diabetes, especially those with poorly controlled blood glucose levels, the amount of 1,5-AG excreted in the urine increases, leading to lower levels of 1,5-AG in the blood. Therefore, measuring the level of 1,5-AG in the blood can provide an indication of the average blood glucose level over the previous 1 to 2 weeks.

Clinical Use[edit | edit source]

The 1,5-AG test is used in conjunction with other tests, such as the HbA1c test, to provide a more complete picture of a patient's glycemic control. The 1,5-AG test can be particularly useful in situations where the HbA1c test may not be reliable, such as in patients with anemia or hemoglobinopathies.

See Also[edit | edit source]

References[edit | edit source]

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