From WikiMD's Food, Medicine & Wellness Encyclopedia


1-Methylindole is an organic compound with the formula C9H9N. It is a derivative of indole, where a methyl group is substituted at the nitrogen atom. This compound is also known as N-Methylindole.

Synthesis[edit | edit source]

1-Methylindole can be synthesized through various methods. One common method involves the Fischer indole synthesis, where a phenylhydrazine reacts with a ketone to form the indole structure, followed by methylation of the nitrogen atom.

Properties[edit | edit source]

1-Methylindole is a colorless to pale yellow liquid with a density of 1.06 g/cm³. It has a melting point of -29°C and a boiling point of 246°C. The compound is slightly soluble in water but is more soluble in organic solvents. It has a refractive index of 1.609 and a flash point of 110°C. The autoignition temperature is 480°C.

Applications[edit | edit source]

1-Methylindole is used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It serves as a building block in the production of more complex molecules and can be used in chemical research.

Safety[edit | edit source]

As with many organic compounds, 1-Methylindole should be handled with care. It is important to use appropriate personal protective equipment (PPE) and follow safety protocols to avoid exposure.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD