From WikiMD's Food, Medicine & Wellness Encyclopedia

1-Phenylcyclohexylamine is a chemical compound that belongs to the class of organic compounds known as amines. It is a primary amine, meaning it has one amine group (-NH2) attached to its structure. The compound is composed of a phenyl group attached to a cyclohexyl group via a single bond.

Structure and Properties[edit | edit source]

The structure of 1-phenylcyclohexylamine consists of a six-membered cyclohexane ring, to which a phenyl group and an amine group are attached. The phenyl group is a six-membered aromatic ring, composed of six carbon atoms with alternating single and double bonds. The amine group consists of a nitrogen atom bonded to two hydrogen atoms.

The compound is a solid at room temperature and has a molar mass of approximately 177.27 g/mol. It is soluble in organic solvents such as ethanol and dichloromethane, but is less soluble in water due to its nonpolar nature.

Synthesis[edit | edit source]

1-Phenylcyclohexylamine can be synthesized through the reaction of phenylmagnesium bromide with cyclohexanone in the presence of an acid. The Grignard reagent, phenylmagnesium bromide, is prepared by the reaction of bromobenzene with magnesium in an ether solution. The resulting Grignard reagent is then reacted with cyclohexanone to form the desired product.

Applications[edit | edit source]

1-Phenylcyclohexylamine is primarily used in the synthesis of other organic compounds. It can act as a precursor to various pharmaceuticals and agrochemicals. For example, it can be used in the synthesis of phencyclidine (PCP), a dissociative drug with hallucinogenic and neurotoxic effects.

Safety and Toxicity[edit | edit source]

As with many organic compounds, 1-phenylcyclohexylamine should be handled with care. It can cause irritation to the skin and eyes, and may be harmful if swallowed or inhaled. Appropriate safety measures should be taken when handling this compound, including the use of personal protective equipment and adequate ventilation.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD