10β,17β-Dihydroxyestra-1,4-dien-3-one

From WikiMD's Food, Medicine & Wellness Encyclopedia

10β,17β-Dihydroxyestra-1,4-dien-3-one is a synthetic, steroidal estrogen and a 17β-hydroxysteroid that is derived from estradiol. It is also known as DHED and is a prodrug of estradiol.

Chemistry[edit | edit source]

10β,17β-Dihydroxyestra-1,4-dien-3-one is a synthetic steroid and a derivative of estradiol. It is specifically a 17β-hydroxysteroid and is also related to other 17β-hydroxysteroids like estrone and estriol.

Pharmacology[edit | edit source]

As a prodrug of estradiol, 10β,17β-Dihydroxyestra-1,4-dien-3-one is converted into estradiol in the body. This conversion is believed to occur in the brain, where it can have estrogenic effects. However, it is not active as an estrogen itself.

Medical uses[edit | edit source]

10β,17β-Dihydroxyestra-1,4-dien-3-one is under investigation for potential medical uses. It may have applications in the treatment of neurodegenerative diseases like Alzheimer's disease, due to its ability to produce estradiol in the brain.

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD