11β-Hydroxydihydrotestosterone

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11%CE%B2-Hydroxydihydrotestosterone

11β-Hydroxydihydrotestosterone (11β-OHDHT) is a metabolite of dihydrotestosterone (DHT), a potent androgen that is derived from testosterone. 11β-OHDHT is formed in the human body through the action of the enzyme 11β-hydroxysteroid dehydrogenase on DHT. This modification introduces a hydroxy group at the 11β-position of the steroid structure, altering its biological activity compared to its parent compound, DHT.

Structure and Function[edit | edit source]

11β-OHDHT retains the core structure of DHT, which is a 19-carbon steroid hormone. The addition of a hydroxy group at the 11β-position impacts the molecule's interaction with androgen receptors (ARs) and its metabolism within the body. The exact physiological role of 11β-OHDHT is less understood compared to DHT, but it is believed to contribute to the overall androgenic activity in tissues where it is produced.

Biosynthesis and Metabolism[edit | edit source]

The biosynthesis of 11β-OHDHT from DHT is catalyzed by the enzyme 11β-hydroxysteroid dehydrogenase. This reaction occurs in various tissues, including the liver, skin, and prostate, where androgen metabolism is active. The presence of 11β-OHDHT has been detected in human plasma, suggesting it circulates systemically and may have endocrine functions beyond its site of synthesis.

Following its production, 11β-OHDHT can undergo further metabolism by other steroidogenic enzymes, leading to the formation of various metabolites. These metabolic pathways play a crucial role in regulating the levels and activity of androgens in the body.

Clinical Significance[edit | edit source]

The clinical significance of 11β-OHDHT is an area of ongoing research. As a metabolite of DHT, it is of interest in studies related to conditions associated with androgen excess, such as polycystic ovary syndrome (PCOS), acne, and prostate cancer. Understanding the role of 11β-OHDHT in these conditions could potentially lead to new therapeutic targets or diagnostic markers.

Research Applications[edit | edit source]

In research settings, 11β-OHDHT is used to study the androgen receptor pathway and the effects of androgens on various biological systems. It serves as a tool to dissect the complex mechanisms of androgen action and to explore the potential therapeutic benefits of modulating this pathway in androgen-related diseases.

Conclusion[edit | edit source]

11β-Hydroxydihydrotestosterone is a biologically active metabolite of DHT with potential implications in androgen physiology and pathology. Further research is needed to fully elucidate its role in health and disease.

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Contributors: Prab R. Tumpati, MD