From WikiMD's Food, Medicine & Wellness Encyclopedia

11-COOH-THC or 11-nor-9-carboxy-Δ9-tetrahydrocannabinol is a secondary metabolite of tetrahydrocannabinol (THC), the active component of cannabis. It is formed in the body after consumption of cannabis and is the primary compound looked for in drug tests to determine cannabis use.

Metabolism[edit | edit source]

THC is metabolized in the liver, primarily by enzymes from the cytochrome P450 family. The most abundant metabolite formed is 11-COOH-THC, which is then conjugated with glucuronic acid and excreted in urine.

Detection[edit | edit source]

11-COOH-THC is the primary metabolite detected in urine drug tests for cannabis use. It can be detected for a longer period of time than THC itself, making it a more reliable marker for recent cannabis use.

Pharmacology[edit | edit source]

Unlike THC, 11-COOH-THC does not have psychoactive effects. However, it has been shown to have anti-inflammatory and analgesic effects, suggesting potential therapeutic uses.

See also[edit | edit source]

11-COOH-THC Resources
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Contributors: Prab R. Tumpati, MD