11-Dehydrothromboxane B2
11-Dehydrothromboxane B2 is a metabolite of thromboxane A2, a compound involved in the blood clotting process. Thromboxane A2 is a potent vasoconstrictor and promoter of platelet aggregation, playing a crucial role in hemostasis and thrombosis.
Biochemistry[edit | edit source]
11-Dehydrothromboxane B2 is formed from the non-enzymatic hydrolysis of thromboxane B2, which itself is a stable metabolite of thromboxane A2. The conversion of thromboxane A2 to thromboxane B2 and subsequently to 11-Dehydrothromboxane B2 occurs in the platelets and other tissues.
Clinical Significance[edit | edit source]
The measurement of 11-Dehydrothromboxane B2 levels in urine or blood can be used as a biomarker for platelet activation and thromboxane production. Elevated levels of this metabolite are associated with increased risk of cardiovascular diseases, such as myocardial infarction and stroke. Monitoring 11-Dehydrothromboxane B2 can be particularly useful in patients undergoing antiplatelet therapy to assess the effectiveness of treatment.
Pathophysiology[edit | edit source]
In conditions such as atherosclerosis, diabetes mellitus, and hypertension, the production of thromboxane A2 and its metabolites, including 11-Dehydrothromboxane B2, is often increased. This contributes to the pathogenesis of these diseases by promoting platelet aggregation and vasoconstriction, leading to the formation of thrombi and vascular complications.
Measurement[edit | edit source]
The quantification of 11-Dehydrothromboxane B2 is typically performed using enzyme-linked immunosorbent assay (ELISA) or mass spectrometry. These methods provide sensitive and specific measurements of the metabolite in biological samples.
Research[edit | edit source]
Ongoing research is focused on understanding the role of 11-Dehydrothromboxane B2 in various diseases and its potential as a therapeutic target. Studies are also exploring the impact of different pharmacological agents on the levels of this metabolite and their implications for disease management.
See also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
