11-Dehydrothromboxane B2

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11-Dehydrothromboxane B2 is a metabolite of thromboxane A2, a compound involved in the blood clotting process. Thromboxane A2 is a potent vasoconstrictor and promoter of platelet aggregation, playing a crucial role in hemostasis and thrombosis.

Biochemistry[edit | edit source]

11-Dehydrothromboxane B2 is formed from the non-enzymatic hydrolysis of thromboxane B2, which itself is a stable metabolite of thromboxane A2. The conversion of thromboxane A2 to thromboxane B2 and subsequently to 11-Dehydrothromboxane B2 occurs in the platelets and other tissues.

Clinical Significance[edit | edit source]

The measurement of 11-Dehydrothromboxane B2 levels in urine or blood can be used as a biomarker for platelet activation and thromboxane production. Elevated levels of this metabolite are associated with increased risk of cardiovascular diseases, such as myocardial infarction and stroke. Monitoring 11-Dehydrothromboxane B2 can be particularly useful in patients undergoing antiplatelet therapy to assess the effectiveness of treatment.

Pathophysiology[edit | edit source]

In conditions such as atherosclerosis, diabetes mellitus, and hypertension, the production of thromboxane A2 and its metabolites, including 11-Dehydrothromboxane B2, is often increased. This contributes to the pathogenesis of these diseases by promoting platelet aggregation and vasoconstriction, leading to the formation of thrombi and vascular complications.

Measurement[edit | edit source]

The quantification of 11-Dehydrothromboxane B2 is typically performed using enzyme-linked immunosorbent assay (ELISA) or mass spectrometry. These methods provide sensitive and specific measurements of the metabolite in biological samples.

Research[edit | edit source]

Ongoing research is focused on understanding the role of 11-Dehydrothromboxane B2 in various diseases and its potential as a therapeutic target. Studies are also exploring the impact of different pharmacological agents on the levels of this metabolite and their implications for disease management.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD