11-ketotestosterone

11-Ketotestosterone (11-KT) is a naturally occurring steroid that is primarily produced in the adrenal glands and testes. It is a potent androgen and is one of the main endogenous androgens in many species of fish.

Structure and Synthesis

11-Ketotestosterone is synthesized from testosterone through the action of the enzyme 11β-HSD. This enzyme catalyzes the conversion of testosterone to 11-KT by adding a keto group at the 11 position on the steroid ring.

Biological Activity

In many species of fish, 11-KT is the primary androgen responsible for the development of male secondary sexual characteristics. It is also involved in the regulation of aggression and reproduction in these species. In humans, the role of 11-KT is less well understood, but it is thought to have similar androgenic effects.

Clinical Significance

Abnormal levels of 11-KT have been associated with a variety of medical conditions. High levels can lead to hyperandrogenism, which can cause symptoms such as acne, hirsutism, and virilization in women. Low levels can lead to hypogonadism, which can cause symptoms such as low libido, fatigue, and infertility in men.

Research

Research into the role of 11-KT in human health and disease is ongoing. Some studies suggest that it may have potential therapeutic applications in the treatment of conditions such as prostate cancer and polycystic ovary syndrome.

See Also

• Androgen
• Testosterone
• 11β-Hydroxysteroid dehydrogenase