12-Methoxy-LSD

A psychedelic drug related to LSD

Chemical structure of 12-Methoxy-LSD

12-Methoxy-LSD (12-MeO-LSD) is a psychedelic drug and a structural analog of lysergic acid diethylamide (LSD). It is part of the ergoline family of compounds and is known for its psychoactive effects, which are similar to those of LSD but with some distinct differences.

Chemical Structure and Properties

12-Methoxy-LSD is chemically classified as a lysergamide. Its structure is similar to that of LSD, with the primary difference being the addition of a methoxy group at the 12th position of the indole ring. This modification alters the compound's pharmacological properties, potentially affecting its potency and duration of action.

The chemical formula of 12-MeO-LSD is C21H27N3O2, and it has a molecular weight of 353.46 g/mol. The presence of the methoxy group is thought to influence the compound's interaction with serotonin receptors, which are believed to be responsible for its psychedelic effects.

Pharmacology

12-Methoxy-LSD acts primarily as a partial agonist at the 5-HT2A receptor, similar to other psychedelics such as LSD and psilocybin. This receptor is a subtype of the serotonin receptor and is heavily involved in the modulation of mood, perception, and cognition.

The effects of 12-MeO-LSD are reported to be similar to those of LSD, including alterations in perception, mood, and thought processes. Users may experience visual and auditory hallucinations, changes in time perception, and a sense of euphoria or introspection.

Effects and Experience

The subjective effects of 12-Methoxy-LSD can vary widely among users, depending on factors such as dosage, individual physiology, and the setting in which the drug is consumed. Common effects include:

• Visual distortions and hallucinations
• Altered sense of time
• Enhanced introspection and creativity
• Emotional variability
• Increased sensory perception

The duration of effects typically lasts between 6 to 12 hours, similar to LSD, although the onset and peak times may differ slightly.

Legal Status

The legal status of 12-Methoxy-LSD varies by country. In many jurisdictions, it is considered a controlled substance due to its structural similarity to LSD and its potential for abuse. In the United States, for example, it may be classified under the Federal Analog Act, which regulates substances that are chemically similar to controlled drugs.

Related Compounds

12-Methoxy-LSD is one of several lysergamides that have been synthesized and studied for their psychoactive properties. Other related compounds include:

• LSD (Lysergic acid diethylamide)
• ALD-52 (1-Acetyl-LSD)
• 1P-LSD (1-Propionyl-LSD)

These compounds share a common core structure but differ in their side chains or functional groups, leading to variations in their pharmacological effects.

Related Pages

• Psychedelic drug
• Serotonin receptor
• Lysergic acid diethylamide
• Hallucinogen