13-Hydroxyoctadecadienoic acid

13-Hydroxyoctadecadienoic acid (13-HODE) is a type of fatty acid that is derived from linoleic acid. It is a member of the hydroxy fatty acids family and is known for its role in various biological processes.

Structure and Synthesis

13-HODE is an oxygenated derivative of linoleic acid, which is an essential fatty acid. It is synthesized in the body through the action of lipoxygenase enzymes, specifically 15-lipoxygenase. The process involves the insertion of an oxygen atom at the 13th carbon of linoleic acid, resulting in the formation of 13-HODE.

Biological Role

13-HODE plays a significant role in several biological processes. It is involved in the regulation of cell proliferation and apoptosis, which are crucial for maintaining the balance of cell growth and death in the body. It also plays a role in inflammation and immune response, acting as a signaling molecule that modulates the activity of immune cells.

In addition, 13-HODE has been implicated in various diseases. Elevated levels of 13-HODE have been observed in patients with cancer, atherosclerosis, and diabetes, suggesting a potential role in the pathogenesis of these conditions.

Research

Research on 13-HODE is ongoing, with studies focusing on its role in disease and potential therapeutic applications. For instance, it has been suggested that targeting the synthesis or action of 13-HODE could be a potential strategy for the treatment of diseases such as cancer and atherosclerosis.

See Also

• Fatty acid
• Linoleic acid
• Lipoxygenase
• Cell proliferation
• Apoptosis
• Inflammation
• Immune response
• Cancer
• Atherosclerosis
• Diabetes

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