17α-Epiestriol

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17α-Epiestriol is a steroidal estrogen and a minor and weak metabolite of estriol. It is one of the many estrogens produced in the body and is known for its role in the endocrine system.

Biochemistry

17α-Epiestriol is synthesized from estrone and estradiol through a series of enzymatic reactions. It is primarily produced in the liver and placenta and is excreted in the urine. The compound has a similar structure to other estrogens, with a hydroxyl group at the 17α position.

Function

As a weak estrogen, 17α-Epiestriol binds to estrogen receptors but with much lower affinity compared to estradiol and estrone. It plays a minor role in the regulation of the menstrual cycle and pregnancy. Its exact physiological functions are not well understood, but it is believed to contribute to the overall estrogenic activity in the body.

Clinical Significance

The levels of 17α-Epiestriol can be measured in the urine and blood to assess estrogen metabolism and function. Abnormal levels may indicate issues with hormone production or metabolism, which can be relevant in conditions such as hormone replacement therapy, menopause, and certain endocrine disorders.

Related Compounds

• Estrone
• Estradiol
• Estriol
• Estrogen

See Also

• Endocrine system
• Hormone
• Menstrual cycle
• Pregnancy