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1DD-LSD structure

1V-LSD (1-valeroyl-lysergic acid diethylamide), also known as Valerie, is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD (lysergic acid diethylamide). It is known for producing psychedelic experiences similar to those of LSD, though with potentially different duration and intensity. The substance has gained attention within the research chemical market where it is often studied for its psychoactive properties and effects on human perception, emotion, and cognition.

Chemistry[edit | edit source]

1V-LSD is a semisynthetic compound of the lysergamide family. It is structurally similar to LSD, with the primary difference being the addition of a valeroyl group attached to the nitrogen atom of the indole ring. This modification is believed to affect the drug's potency, duration, and metabolic profile. Like other lysergamides, 1V-LSD is believed to act primarily as an agonist at serotonin receptors in the brain, particularly at the 5-HT2A receptor, which plays a significant role in its psychedelic effects.

Pharmacology[edit | edit source]

The pharmacological action of 1V-LSD involves its interaction with serotonin receptors in the brain, similar to other psychedelics like LSD. Its exact mechanism of action is complex and not fully understood, but it is thought to work by binding to and activating the 5-HT2A receptor, leading to alterations in perception, mood, and thought. The addition of the valeroyl group may influence its affinity for different receptors or its metabolism, potentially altering its effects compared to LSD.

Effects[edit | edit source]

The effects of 1V-LSD are reported to be similar to those of LSD, including alterations in perception, mood, and thought. Users may experience visual hallucinations, enhanced emotional experiences, and a distorted sense of time. The intensity and duration of its effects can vary based on the dose, individual physiology, and other factors. However, due to its legal status and classification as a research chemical, comprehensive studies on its effects, especially long-term, are limited.

Legal Status[edit | edit source]

The legal status of 1V-LSD varies by country, with some jurisdictions classifying it as a controlled substance, thereby restricting its sale, possession, and use. In other areas, it may exist in a legal gray area, being sold as a research chemical not intended for human consumption. Users and researchers should be aware of their local laws before acquiring or using 1V-LSD.

Safety[edit | edit source]

As with any psychoactive substance, the safety profile of 1V-LSD is an important consideration. Due to its relatively recent appearance on the research chemical market, there is limited data on its toxicity, long-term effects, and potential for abuse. Users are advised to exercise caution, adhere to harm reduction practices, and be aware of the legal and health risks associated with its use.


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Contributors: Prab R. Tumpati, MD