2,3-Dimercapto-1-propanesulfonic acid
2,3-Dimercapto-1-propanesulfonic acid (also known as DMPS) is a water-soluble compound that is used as a chelating agent. It is particularly effective in the treatment of heavy metal poisoning, including mercury, arsenic, and lead poisoning.
History[edit | edit source]
DMPS was first synthesized in the 1950s by the Heyl Brothers company in Berlin, Germany. It was initially used in the treatment of arsenic poisoning, but its use has since expanded to include other types of heavy metal poisoning.
Pharmacology[edit | edit source]
DMPS works by binding to heavy metals in the body, forming a stable complex that can be excreted in the urine. This process is known as chelation therapy. DMPS is a dithiol compound, meaning it has two sulfhydryl groups which are responsible for its chelating properties.
Uses[edit | edit source]
DMPS is used in the treatment of acute and chronic heavy metal poisoning. It is particularly effective in cases of mercury, arsenic, and lead poisoning. It is also used in the diagnosis of these conditions, as the amount of metal excreted in the urine after administration of DMPS can give an indication of the level of metal exposure.
Side Effects[edit | edit source]
Like all medications, DMPS can have side effects. These can include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause more serious side effects such as kidney damage and hypotension.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
