From WikiMD's Food, Medicine & Wellness Encyclopedia

2,4,5-Trimethoxyphenethylamine (also known as 2C-T-21 and often abbreviated as TMA-2) is a psychedelic drug of the phenethylamine class. It is a derivative of mescaline and is a member of the 2C family of psychedelic phenethylamines.

Chemistry[edit | edit source]

2,4,5-Trimethoxyphenethylamine is a synthetic compound of the phenethylamine class. Its chemical structure consists of a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional three methoxy groups (O-CH3) at the 2, 4, and 5 positions of the phenyl ring.

Pharmacology[edit | edit source]

The exact mechanism of action for 2,4,5-Trimethoxyphenethylamine is not fully understood. However, it is believed to work primarily by binding to serotonin receptors in the brain, specifically the 5-HT2A receptor. This receptor is known to play a key role in the cognitive effects of many psychedelic substances.

Effects[edit | edit source]

The effects of 2,4,5-Trimethoxyphenethylamine can vary greatly depending on the dose, individual physiology, and set and setting. Common effects reported by users include visual hallucinations, enhanced sensory perception, altered sense of time, and euphoria. Some users also report experiencing introspective insights or spiritual experiences.

Risks[edit | edit source]

As with all psychedelic substances, 2,4,5-Trimethoxyphenethylamine carries risks. These can include psychological distress, panic attacks, and rare cases of psychosis in predisposed individuals. Physically, it can cause nausea, increased heart rate, and increased blood pressure.

Legal Status[edit | edit source]

The legal status of 2,4,5-Trimethoxyphenethylamine varies by country. In the United States, it is classified as a Schedule I controlled substance, making it illegal to manufacture, buy, possess, or distribute without a license.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD