From WikiMD's Food, Medicine & Wellness Encyclopedia

2,4,5-Trimethoxyphenethylamine (also known as 2C-T-21 and Aleph-21) is a psychedelic drug and phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and documented in his book PiHKAL.

Chemistry[edit | edit source]

2,4,5-Trimethoxyphenethylamine is a synthetic molecule of the phenethylamine class. Molecules of this class contain a phenyl ring bound to an amino (NH2) group through an ethyl chain with additional substitutions at R2 and R5 of the phenyl ring with three methoxy groups (O-CH3).

Pharmacology[edit | edit source]

The mechanism that produces the hallucinogenic and entheogenic effects of 2,4,5-Trimethoxyphenethylamine is most likely to result from action as a 5-HT2A receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.

Effects[edit | edit source]

The effects of 2,4,5-Trimethoxyphenethylamine are usually compared to those of other psychedelic phenethylamines such as 2C-B and 2C-I. These effects include open and closed eye visuals, time distortion, enhanced introspection, and ego loss. Its effects can be described as a hybrid between MDMA and LSD, but it is not as potent as either.

Legality[edit | edit source]

2,4,5-Trimethoxyphenethylamine is currently a gray area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries, but people may still be charged for its possession under certain circumstances such as under analogue laws and with the intent to sell or consume.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD